EXPLORING THE PROGRESSION OF DRUG DEPENDENCE IN A METHAMPHETAMINE SELF-ADMINISTRATION RAT MODEL THROUGH TARGETED AND NON-TARGETED METABOLOMICS ANALYSES

Abstract Persistent neurochemical and biological disturbances resulting from repeated cycles of drug reward, withdrawal, and relapse contribute to drug dependence.Methamphetamine (MA) is a psychostimulant with substantial abuse potential and neurotoxic effects, primarily affecting monoamine neurotransmitter systems in the brain.In this study, we ai

p53 tumour suppressor gene is our major barrier against neoplastic transformation.It is involved in many cellular functions, including cell cycle arrest, senescence, DNA repair, apoptosis, autophagy, cell metabolism, ferroptosis, immune system regulation, generation of reactive oxygen species, mitochondrial function, global regulation of gene curry

Humans have been using fire for hundreds of millennia, creating an ancestral expansion toward the nocturnal niche.The new adaptive challenges faced at night were recurrent enough to amplify existing psychological variation in our species.Night-time is dangerous and mysterious, so it selects for individuals with higher tendencies for paranoia, risk-

With the present state of the direct current (DC) distribution market, securing the safety of the DC wella peach blush mask distribution system is emerging as a major issue.Like AC distribution systems, DC switches and circuit breakers are one of the main means to ensure safety.However, in the DC system, since there is no current zero point in the